To Live or to Die: Prosurvival Activity of PPAR𝜸 in Cancers

Table 2

Peak plasma concentrations of PPAR𝛾 agonists.

Agonists	𝐂max^(a) (𝝁M)	References
Ciglitazone	15~30(b)	[8]
Pioglitazone	0.2~2.5	[9]
Rosiglitazone	0.2~1.7	Avandia Prescribing Information(c)
Troglitazone	0.7~8.8	[10]
15d-PGJ2	Low nanomolar to picomolar range(d)	[11]
		[12]

(a)𝐶_max, the maximum or peak plasma concentration in human unless otherwise indicated.
(b)That in dog plasma.
(c)From http://us.gsk.com/products/assets/us_avandia.pdf.
(d)Physiological concentrations in cerebrospinal fluid, urine, and the interior of adipocytes.