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PPAR Research
Volume 2008, Article ID 247379, 8 pages
http://dx.doi.org/10.1155/2008/247379
Review Article

PPAR 𝛾 and PPAR 𝛿 as Modulators of Neoplasia and Cell Fate

Department of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USA

Received 9 May 2008; Accepted 22 May 2008

Academic Editor: Dipak Panigrahy

Copyright © 2008 Robert I. Glazer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PPAR 𝛾 and PPAR 𝛿 agonists represent unique classes of drugs that act through their ability to modulate gene transcription associated with intermediary metabolism, differentiation, tumor suppression, and in some instances proliferation and cell adhesion. PPAR 𝛾 agonists are used by millions of people each year to treat type 2 diabetes but may also find additional utility as relatively nontoxic potentiators of chemotherapy. PPAR 𝛿 agonists produce complex actions as shown by their tumor promoting effects in rodents and their cholesterol-lowering action in dyslipidemias. There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. This review discusses the role of PPAR 𝛾 and PPAR 𝛿 agonists as modulators of these processes.