Genetic Polymorphisms of Peroxisome Proliferator-Activated Receptors and the Risk of Cardiovascular Morbidity and Mortality in a Community-Based Cohort in Washington County, Maryland

Table 4

Age-adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) of premature (age <65 years) all-cause and cardiovascular mortality for 5 PPAR SNPs. Person years: cumulative person years of follow up.

		All-cause death		CV-related death
SNPs	Person years	n	HR (95% CI)	n	HR (95% CI)
PPARG rs4684847
CC	43445	231	1.00 (reference)	27	1.00 (reference)
CT/TT	11743	58	1.05 (0.78–1.40)	4	0.60 (0.21–1.72)
PPARG rs709158
AA	23078	115	1.00 (reference)	13	1.00 (reference)
AG/GG	32822	175	1.05 (0.83–1.33)	18	0.95 (0.47–1.95)
PPARG rs1175543
AA	22875	115	1.00 (reference)	14	1.00 (reference)
AG/GG	32859	175	1.04 (0.82–1.32)	17	0.83 (0.41–1.68)
PPARD rs2016520
CC	36389	186	1.00 (reference)	21	1.00 (reference)
CT/TT	19940	99	0.98 (0.77–1.25)	9	0.79 (0.36–1.71)
PPARG rs1801282
Pro/Pro	44263	236	1.00 (reference)	25	1.00 (reference)
Pro/Ala or Ala/Ala	12247	50	0.90 (0.66–1.23)	5	0.79 (0.30–2.09)