Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2008, Article ID 293538, 6 pages
http://dx.doi.org/10.1155/2008/293538
Review Article

PPAR/-Independent Effects of PPAR/ Ligands on Cysteinyl Leukotriene Production in Mast Cells

Laboratory of Food Science, Department of Bioresource Science, Nihon University Junior College, 1866 Kameino, Fujisawa 252-8510, Japan

Received 3 March 2008; Revised 5 June 2008; Accepted 15 September 2008

Academic Editor: Francine M. Gregoire

Copyright © 2008 Masamichi Yamashita. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Natioal Heart Lung and Blood Institute, “Guidelines for the diagnosis and management of asthma (EPR-3),” Tech. Rep. NIH 08-4051, Natioal Heart Lung and Blood Institute, Bethesda, Md, USA, 2007. View at Google Scholar
  2. J. M. Brown, T. M. Wilson, and D. D. Metcalfe, “The mast cell and allergic diseases: role in pathogenesis and implications for therapy,” Clinical & Experimental Allergy, vol. 38, no. 1, pp. 4–18, 2008. View at Publisher · View at Google Scholar
  3. P. Christmas, B. M. Weber, M. McKee, D. Brown, and R. J. Soberman, “Membrane localization and topology of leukotriene C4 synthase,” The Journal of Biological Chemistry, vol. 277, no. 32, pp. 28902–28908, 2002. View at Publisher · View at Google Scholar
  4. M. Raulf, M. Stuning, and W. Konig, “Metabolism of leukotrienes by L-γ-glutamyl-transpeptidase and dipeptidase from human polymorphonuclear granulocytes,” Immunology, vol. 55, no. 1, pp. 135–147, 1985. View at Google Scholar
  5. A. H. Dantzig, R. L. Shepard, K. L. Law et al., “Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities,” The Journal of Pharmacology and Experimental Therapeutics, vol. 290, no. 2, pp. 854–862, 1999. View at Google Scholar
  6. G. W. James, “The use of the in vivo trachea preparation of the guinea-pig to asses drug action on lung,” Journal of Pharmacy and Pharmacology, vol. 21, no. 6, pp. 379–386, 1969. View at Google Scholar
  7. C. E. Heise, B. F. O'Dowd, D. J. Figueroa et al., “Characterization of the human cysteinyl leukotriene 2 receptor,” The Journal of Biological Chemistry, vol. 275, no. 39, pp. 30531–30536, 2000. View at Publisher · View at Google Scholar
  8. K. R. Lynch, G. P. O'Neill, Q. Liu et al., “Characterization of the human cysteinyl leukotriene CysLT1 receptor,” Nature, vol. 399, no. 6738, pp. 789–793, 1999. View at Publisher · View at Google Scholar
  9. B. Dahlén, E. Nizankowska, A. Szczeklik et al., “Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 4, pp. 1187–1194, 1998. View at Google Scholar
  10. T. F. Reiss, C. A. Sorkness, W. Stricker et al., “Effects of montelukast (MK-0476), a potent cysteinyl leukotriene receptor antagonist, on bronchodilation in asthmatic subjects treated with and without inhaled corticosteroids,” Thorax, vol. 52, no. 1, pp. 45–48, 1997. View at Google Scholar
  11. J. E. Fish, J. P. Kemp, R. F. Lockey, M. Glass, L. A. Hanby, and C. M. Bonuccelli, “Zafirlukast for symptomatic mild-to-moderate asthma: a 13-week multicenter study,” Clinical Therapeutics, vol. 19, no. 4, pp. 675–690, 1997. View at Publisher · View at Google Scholar
  12. N. C. Barnes and J.-C. Pujet, “Pranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma,” Thorax, vol. 52, no. 6, pp. 523–527, 1997. View at Google Scholar
  13. M. Yamashita, “Peroxisome proliferator-activated receptor α-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells,” European Journal of Pharmacology, vol. 556, no. 1–3, pp. 172–180, 2007. View at Publisher · View at Google Scholar
  14. C. J. Nicol, M. Yoon, J. M. Ward et al., “PPAR? influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis,” Carcinogenesis, vol. 25, no. 9, pp. 1747–1755, 2004. View at Publisher · View at Google Scholar
  15. G. Krey, O. Braissant, F. L'Horset et al., “Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay,” Molecular Endocrinology, vol. 11, no. 6, pp. 779–791, 1997. View at Publisher · View at Google Scholar
  16. N. Latruffe and J. Vamecq, “Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism,” Biochimie, vol. 79, no. 2-3, pp. 81–94, 1997. View at Publisher · View at Google Scholar
  17. M. Yamashita, M. Kushihara, N. Hirasawa et al., “Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells,” British Journal of Pharmacology, vol. 129, no. 2, pp. 367–373, 2000. View at Publisher · View at Google Scholar
  18. K. Okuyama, M. Yamashita, Y. Kitabatake, S. Kawamura, M. Takayanagi, and I. Ohno, “Ciglitazone inhibits the antigen-induced leukotrienes production independently of PPARγ in RBL-2H3 mast cells,” European Journal of Pharmacology, vol. 521, no. 1–3, pp. 21–28, 2005. View at Publisher · View at Google Scholar
  19. J. T. Huang, J. S. Welch, M. Ricote et al., “Interleukin-4-dependent production of PPAR-? ligands in macrophages by 12/15-lipoxygenase,” Nature, vol. 400, no. 6742, pp. 378–382, 1999. View at Publisher · View at Google Scholar
  20. H. N. Sørensen, E. Hvattum, E. J. Paulssen, K. M. Gautvik, J. Bremer, and Ø. Spydevold, “Induction of peroxisomal acyl-CoA oxidase by 3-thia fatty acid, in hepatoma cells and hepatocytes in culture is modified by dexamethasone and insulin,” Biochimica et Biophysica Acta, vol. 1171, no. 3, pp. 263–271, 1993. View at Publisher · View at Google Scholar
  21. J. D. Tugwood, I. Issemann, R. G. Anderson, K. R. Bundell, W. L. McPheat, and S. Green, “The mouse peroxisome proliferator activated receptor recognizes a response element in the 5 flanking sequence of the rat acyl CoA oxidase gene,” The EMBO Journal, vol. 11, no. 2, pp. 433–439, 1992. View at Google Scholar
  22. T. Helledie, L. Gróntved, S. S. Jensen et al., “The gene encoding the acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor ? through an intronic response element functionally conserved between humans and rodents,” The Journal of Biological Chemistry, vol. 277, no. 30, pp. 26821–26830, 2002. View at Publisher · View at Google Scholar
  23. B. L. Diaz, H. Fujishima, Y. Kanaoka, Y. Urade, and J. P. Arm, “Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids,” The Journal of Immunology, vol. 168, no. 3, pp. 1397–1404, 2002. View at Google Scholar
  24. A. Tautenhahn, B. Brüne, and A. von Knethen, “Activation-induced PPARγ expression sensitizes primary human T cells toward apoptosis,” Journal of Leukocyte Biology, vol. 73, no. 5, pp. 665–672, 2003. View at Publisher · View at Google Scholar
  25. K. Maeyama, M. Emi, and M. Tachibana, “Nuclear receptors as targets for drug development: peroxisome proliferator-activated receptor γ in mast cells: its roles in proliferation and differentiation,” Journal of Pharmacological Sciences, vol. 97, no. 2, pp. 190–194, 2005. View at Publisher · View at Google Scholar
  26. J. E. Ward and X. Tan, “Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease,” PPAR Research, vol. 2007, Article ID 14983, 12 pages, 2007. View at Publisher · View at Google Scholar
  27. S. Paruchuri, Y. Jiang, C. Feng, S. A. Francis, J. Plutzky, and J. A. Boyce, “Leukotriene E4 activates peroxisome proliferator-activated receptor γ and induces prostaglandin D2 generation by human mast cells,” The Journal of Biological Chemistry, vol. 283, no. 24, pp. 16477–16487, 2008. View at Publisher · View at Google Scholar
  28. X. Zhang, N. Tanaka, T. Nakajima, Y. Kamijo, F. J. Gonzalez, and T. Aoyama, “Peroxisome proliferator-activated receptor α-independent peroxisome proliferation,” Biochemical and Biophysical Research Communications, vol. 346, no. 4, pp. 1307–1311, 2006. View at Publisher · View at Google Scholar
  29. C. Banfi, J. Auwerx, F. Poma, E. Tremoli, and L. Mussoni, “Induction of plasminogen activator inhibitor I by the PPARα ligand, Wy-14,643, is dependent on ERK 1/2 signaling pathway,” Thrombosis and Haemostasis, vol. 90, no. 4, pp. 611–619, 2003. View at Google Scholar
  30. C. J. Pauley, B. J. Ledwith, and C. Kaplanski, “Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor α-independent mechanisms,” Cellular Signalling, vol. 14, no. 4, pp. 351–358, 2002. View at Publisher · View at Google Scholar
  31. A. M. Lennon, M. Ramaugé, A. Dessouroux, and M. Pierre, “MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Δ12,14-prostaglandin J2 and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor γ-independent mechanisms involving reactive oxygenated species,” The Journal of Biological Chemistry, vol. 277, no. 33, pp. 29681–29685, 2002. View at Publisher · View at Google Scholar
  32. S. Goetze, X.-P. Xi, Y. Kawano et al., “TNF-a-induced migration of vascular smooth muscle cells is MAPK dependent,” Hypertension, vol. 33, no. 1, pp. 183–189, 1999. View at Google Scholar
  33. M. Caivano, C. Rodriguez, P. Cohen, and S. Alemany, “15-deoxy-Δ12,14-prostaglandin J2 regulates endogenous cot MAPK kinase kinase 1 activity induced by lipopolysaccharide,” The Journal of Biological Chemistry, vol. 278, no. 52, pp. 52124–52130, 2003. View at Publisher · View at Google Scholar
  34. O. Werz, J. Klemm, B. Samuelsson, and O. Rådmark, “5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 10, pp. 5261–5266, 2000. View at Publisher · View at Google Scholar
  35. Z.-Z. Shi, B. Han, G. M. Habib, M. M. Matzuk, and M. W. Lieberman, “Disruption of γ-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response,” Molecular and Cellular Biology, vol. 21, no. 16, pp. 5389–5395, 2001. View at Publisher · View at Google Scholar
  36. G. M. Habib, Z.-Z. Shi, A. A. Cuevas, Q. Guo, M. M. Matzuk, and M. W. Lieberman, “Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 9, pp. 4859–4863, 1998. View at Publisher · View at Google Scholar
  37. R. S. Peebles and H. P. Glauert, “Effect of phenobarbital on hepatic eicosanoid concentrations in rats,” Archives of Toxicology, vol. 71, no. 10, pp. 646–650, 1997. View at Publisher · View at Google Scholar
  38. Y. Fujimura, H. Tachibana, and K. Yamada, “Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor FcεRI in human basophilic KU812 cells,” Biochemical and Biophysical Research Communications, vol. 297, no. 2, pp. 193–201, 2002. View at Publisher · View at Google Scholar
  39. S. S.-T. Lee, T. Pineau, J. Drago et al., “Targeted disruption of the a isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators,” Molecular and Cellular Biology, vol. 15, no. 6, pp. 3012–3022, 1995. View at Google Scholar
  40. N. Kubota, Y. Terauchi, H. Miki et al., “PPAR? mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance,” Molecular Cell, vol. 4, no. 4, pp. 597–609, 1999. View at Publisher · View at Google Scholar
  41. S. S. Deeb, L. Fajas, M. Nemoto et al., “A Pro12Ala substitution in PPAR? 2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity,” Nature Genetics, vol. 20, no. 3, pp. 284–287, 1998. View at Publisher · View at Google Scholar