PPAR Research / 2008 / Article / Fig 2

Research Article

Statins Activate Human PPAR 𝛼 Promoter and Increase PPAR 𝛼 mRNA Expression and Activation in HepG2 Cells

Figure 2

PPAR mRNA expression in HepG2 cells after treatment with atorvastatin (Ator), cerivastatin (Ceri), fluvastatin (Flu), pitavastatin (Pita), pravastatin (Pra), rosuvastatin (Rosu), and simvastatin (Sim) for 24 hours. (a) Each statin was used at concentrations of 5, 10, and . Nontreated cells (statin concentration ) were the control. (b) Pravastatin was used at higher concentrations of 20, 50, 100, and . Nontreated cells (pravastatin concentration ) were the control. The data are expressed as % of controls. Values are presented as the mean SEM of three separate experiments, significantly different from control at , .

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