Statins Activate Human PPAR Promoter and Increase PPAR mRNA Expression and Activation in HepG2 Cells
Figure 3
PPAR promoter activity in HepG2 cells transfected
with human PPAR promoter-reporter plasmid after treatment with
atorvastatin (Ator), cerivastatin (Ceri), fluvastatin (Flu), pitavastatin
(Pita), pravastatin (Pra), rosuvastatin (Rosu), and simvastatin (Sim) for 24
hours. Each statin was used at doses of 1, 10, 25, and . Nontreated cells (statin concentration ) were the control. The data are expressed as
% of controls. Values are presented as the mean SEM of three separate experiments, significantly
different from control at , .