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PPAR Research
Volume 2008 (2008), Article ID 364784, 9 pages
http://dx.doi.org/10.1155/2008/364784
Review Article

Hexarelin Signaling to PPAR 𝛾 in Metabolic Diseases

1Research Center, Ste-Justine Hospital, University of Montreal, Montréal, PQ, Canada H3T 1C5
2Department of Biochemistry, University of Montreal, Montréal, PQ, Canada H3T 1J4
3Department of Obstetrics and Gynecology, University of Montreal, Montréal, PQ, Canada H3T 1C5

Received 7 August 2007; Accepted 27 November 2007

Academic Editor: Brian N. Finck

Copyright © 2008 Annie Demers et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor 𝛾 (PPAR 𝛾 ) has been extremely rewarding over the past years. Uncovering the biologic roles of PPAR 𝛾 and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPAR 𝛾 have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPAR 𝛾 through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases.