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PPAR Research
Volume 2008, Article ID 436489, 10 pages
http://dx.doi.org/10.1155/2008/436489
Review Article

PPAR 𝛾 : The Portrait of a Target Ally to Cancer Chemopreventive Agents

1Department of Biological Applications and Technologies, University of Ioannina, Ioannina 45110, Greece
2Institute of Cancer Research, Royal Cancer Hospital, Sutton Surrey, London SM2 5NG, UK
3Department of Medical Oncology, School of Medicine, University of Ioannina, Ioannina 45110, Greece

Received 4 March 2008; Revised 22 May 2008; Accepted 16 July 2008

Academic Editor: Dipak Panigrahy

Copyright © 2008 Ioannis Sainis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor-gamma (PPAR 𝛾 ), one of three ligand-activated transcription factors named PPAR, has been identified as a molecular target for cancer chemopreventive agents. PPAR 𝛾 was initially understood as a regulator of adipocyte differentiation and glucose homeostasis while later on, it became evident that it is also involved in cell differentiation, apoptosis, and angiogenesis, biological processes which are deregulated in cancer. It is now established that PPAR 𝛾 ligands can induce cell differentiation and yield early antineoplastic effects in several tumor types. Moreover, several bioactive natural products with cancer protecting potential are shown to operate through activation of PPAR 𝛾 . Overall, PPAR 𝛾 appears to be a prevalent target ally to cancer chemopreventive agents and therefore pursuing research in this area is of great relevance.