Research Article

Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- 𝛾 Agonist

Table 1

Binding of MBX-102 acid to rat, mouse, and human plasma determined by equilibrium dialysis. Binding of [3H] MBX-102 acid to plasma was conducted by equilibrium dialysis against PBS buffer at 37°C and the percentage of total radiolabel bound to plasma was determined by dividing the amount of sample in the plasma compartment by the combined total amounts in the plasma and PBS buffer compartments. Values represent the result of a representative experiment and are the mean ± SD of triplicate determinations.

MBX-102 acid (μM) %Protein Binding ± SD
Human Mouse Rat

400
600
1000
1500 100 ± 0.1
2000