Research Article
Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR- Agonist
Table 1
Binding of MBX-102 acid to rat, mouse, and human plasma
determined by equilibrium dialysis. Binding of [3H] MBX-102 acid
to plasma was conducted by equilibrium dialysis against PBS buffer at 37°C
and the percentage
of total radiolabel bound to plasma was determined by dividing the amount of
sample in the plasma compartment by the combined total amounts in the plasma
and PBS buffer compartments. Values represent the result of a representative
experiment and are the mean ± SD of triplicate determinations.
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