PPAR Research / 2008 / Article / Fig 1

Review Article

The Critical Role of PPAR in Human Malignant Melanoma

Figure 1

Activating pathways known to be constitutively active and contributing to the chemoresistance of melanoma cells. Over 60% of melanomas have activating mutations of B-RAF, 30% have lost PTEN expression, majority with NF-κB activation.

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