The Critical Role of PPAR𝜸 in Human Malignant Melanoma

Table 1

Effects of PPARγ agonists on melanoma cell growth.

Cell line	PPARγ agonist	Concentration	Results	Mechanism of action	Reference
UISO-Mel6,	Rosiglitazone,	0.3–300 𝜇M	– Growth inhibition of all cell lines at	– Independent from apoptosis	Freudlsperger et al. [28]
MV3, MeWo,	pioglitazone,		30–300 𝜇M,
G361,	ciglitazone,		– increase in cell proliferation at
Lox	troglitazone		3 𝜇M
MM-358,	15d-PGJ2,	0.1–50 𝜇M	– Growth inhibtion of all cell lines at 20–50 𝜇M	– Independent from apoptosis,	Mössner et al. [29]
MM-201,	troglitazone,			– induction of G1 phase
MM-254, KAII	rosiglitazone			cell cycle arrest
SK-mel28, A375	Ciglitazone,	0–10 𝜇M	– Growth inhbition only of A375 at 10 𝜇M	– Not investigated	Eastham et al. [27]
	troglitazone,
	15d-PGJ2
WM35, A375	Ciglitazone,	10–15 𝜇M	– Growth inhibition of all cell lines at	– Induction of apoptosis	Placha et al. [30]
	15d-PGJ2		10–15 𝜇M
A375	Ciglitazone,	0–32 𝜇M	– Growth inhibtion of A375 at 16 𝜇M of 15d-PGJ2	– Induction of apoptosis	Núñez et al. [31]
	15d-PGJ2,		– no growth inhibition by ciglitazone