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PPAR Research
Volume 2008, Article ID 517162, 7 pages
http://dx.doi.org/10.1155/2008/517162
Review Article

Potential Therapeutic Targets for PPAR 𝜸 after Spinal Cord Injury

Department of Neuroscience and Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH 43210, USA

Received 3 December 2007; Accepted 7 January 2008

Academic Editor: Paul Drew

Copyright © 2008 Dana M. McTigue. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Traumatic injury to the spinal cord results in multiple anatomical, physiological, and functional deficits as a result of local neuronal and glial cell death as well as loss of descending and ascending axons traversing the injury site. The many different mechanisms thought to contribute to protracted secondary cell death and dysfunction after spinal cord injury (SCI) are potential therapeutic targets. Agents that bind and activate the transcription factor peroxisome proliferator-activated receptor- 𝛾 (PPAR- 𝛾 ) show great promise for minimizing or preventing these deleterious cascades in other models of CNS disorders. This review will summarize the major secondary injury cascades occurring after SCI and discuss data from experimental CNS injury and disease models showing the exciting potential for PPAR 𝛾 therapies after SCI.