The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products
Figure 1
Mechanism of PPAR action. PPARs in response to ligand binding in the cytosol, dimerize with RXR, recruit
coactivators and release corepressor; in the nucleus a multimolecule complex, formed by PPAR, PPAR ligand, RXR, RXR-ligand,
and accessory proteins bind PPRE DNA sequences in the promoters of target genes.