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PPAR Research
Volume 2008, Article ID 546753, 6 pages
Review Article

PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis

1Department of Neurology, The Ohio State University Medical Center, 1654 Upham Drive, 445 Means Hall, Columbus, OH 43210, USA
2Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
3Department of Molecular Virology, Immunology & Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
4Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

Received 7 March 2008; Accepted 5 June 2008

Academic Editor: Saleh Ibrahim

Copyright © 2008 Yuhong Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in the regulation of lipid metabolism, energy balance, artherosclerosis and glucose control. Recent studies suggest that they play an important role in regulating inflammation. This review will focus on PPAR- 𝛼 regulation of the immune response. We describe how PPAR- 𝛼 regulates differentiation of T cells by transactivation and/or interaction with other transcription factors. Moreover, PPAR- 𝛼 agonists have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in mice, suggesting that they could provide a therapy for human autoimmune diseases such as multiple sclerosis.