PPAR Ligands for Cancer Chemoprevention

Table 3

Clinical trials on the anticancer effects of PPARγ ligands.

Clinical trials	Drug	Results	Reference no.
Patients with intermediate to high-grade liposarcomas (case reports)	Troglitazone	Histlogical and biochemical differentiation	[90]
Phase II study on patients with histologically-confirmed prostate cancer and no symptomatic metastatic disease	Troglitazone	Lengthened stabilization of prostate-specific antigen	[91]
75-year-old patient with an occult recurrent prostate cancer (case reports)	Troglitazone	Reduced prostate-specific antigen	[92]
Phase II study on patients with metastatic colon cancer	Troglitazone	No significant effect	[93]
Phase II study on patients with liposarcoma	Rosiglitazone	Lengthened mean time of progression	[94]
Phase II study on patients with refractory breast cancer	Troglitazone	No significant effect	[95]
Phase II study on patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer	Rosiglitazone	Induced radioiodine uptake	[96]
Phase I study on patients with solid tumors	LY293111	The recommended oral dose (600 mg/day) for phase II trial	[97]