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PPAR Research
Volume 2008 (2008), Article ID 614852, 5 pages
http://dx.doi.org/10.1155/2008/614852
Review Article

Regulation of Cell Proliferation and Differentiation by PPAR

Institute of Molecular Biology and Tumor Research (IMT), Philipps-University, Emil-Mannkopff-Strasse 2, 35032 Marburg, Germany

Received 23 July 2008; Accepted 13 August 2008

Academic Editor: Francine M. Gregoire

Copyright © 2008 Rolf Müller et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor- (PPAR ) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In addition, there is strong evidence that PPAR modulates oncogenic signaling pathways and tumor growth. Consistent with these observations, numerous reports have clearly documented a role for PPAR in cell cycle control, differentiation, and apoptosis. However, the precise role of PPAR in tumorigenesis and cell proliferation remains controversial. This review summarizes our current knowledge and proposes a model corroborating the discrepant data in this area of research.