PPAR Regulation of Inflammatory Signaling in CNS Diseases
Figure 1
(a) Functional domains of PPAR isoforms. N, N-terminus; DBD: DNA-binding domain; LBD: ligand-binding domain. The numbers represent percentage identity to human PPAR. (b) PPAR/RXR binds to PPREDR-1 promoter regions. Binding of agonists leads to heterodimerization, recruitment of coactivator and transcriptional activation of target genes.
