Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template

<table> Chemical structure of our PPAR/-dual agonist TIPP-401, and the synthetic route. Reagents and
conditions: (i) BH3-tetrahydrofuran,
THF, 0°C, (j) activated MnO2, CH2Cl2, r.t., (k)
2-fluoro-4-trifluoromethylbenzamide, triethylsilane, trifluoroacetic acid,
toluene, reflux, (l) LiOH H2O, H2O2,
THF-H2O, 0°C.</table>

PPAR Research

sch2

Scheme 2

Scheme 2: Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template 

Scheme 2 | Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template 