Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template

Table 3

Species differences in the transactivation of PPAR𝛼 isoforms.

	Transactivation activity
	EC50 (nM)^(a)
Compd.	Human	Dog	Rat
KCL	60	160	5200
fenofibrate	41000	50000	49000

^(a) See footnote of Table 1.