PPAR𝛾 and Apoptosis in Cancer

Table 1

PPAR agonists induce apoptosis in cancer.

PPAR agonist	PPAR	Tumor type	Molecular mediator(s) of apoptosis	Reference
15d-PGJ2	Independent	Breast	Unknown	[8]
Troglitazone and 15d-PGJ2	Dependent	Thyroid	c-myc	[9]
Ciglitazone	Dependent	Thyroid	PPAR	[10]
Rosiglitazone	Dependent	Thyroid	NF-B, cyclinD1, caspase-3	[11]
Troglitazone and 15d-PGJ2	Unknown	Colon	c-myc, c-jun, GADD153	[12]
Troglitazone	Dependent	Lung	GADD153	[13]
Troglitazone	Independent	Colon	EGR-1, NAG-1	[14, 15]
15d-PGJ2	Dependent	Colon	EGR-1, NAG-1	[15]
Troglitazone	Dependent	Lung	ERK1/2	[16]
Troglitazone	Dependent and independent	Colon	p53, POX	[17]
Troglitazone	Independent	Prostate	Bcl-2, Bcl-XL	[18]
15d-PGJ2	Independent	Oral	Stat3	[19]
15d-PGJ2	Independent	Prostate, bladder	Caspase-3, -7	[20]
15d-PGJ2	Independent	Multiple myeloma, burkitt lymphoma	NF-kappa-B, cIAP-1, XIAP, c-FLIP	[21]
Rosiglitazone	Dependent	Breast	PPAR, p53	[22]