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PPAR Research
Volume 2008, Article ID 758562, 9 pages
Review Article

Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition

1Université d'Auvergne, JE 2447, ARDEMO, Clermont-Ferrand 63000, France
2INSERM, U.384, Laboratoire de Biochimie, Faculté de Médecine, Clermont-Ferrand 63000, France
3CHU Clermont-Ferrand, Maternité, Hôtel-Dieu, Clermont-Ferrand 63000, France

Received 4 June 2007; Revised 13 August 2007; Accepted 26 October 2007

Academic Editor: Pascal Froment

Copyright © 2008 Valerie Borel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. This placental involvement has been recently reviewed focusing on the early stages of placental development (implantation and invasion, etc.), mouse PPARs knockout phenotypes, and cytotrophoblast physiology. In this review, we describe the placental involvement of PPARs (e.g., fat transport and metabolism, etc.) during the late stages of gestation and in the amniotic membranes, highlighting their roles in the inflammation process (e.g., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.