The Role of PPARs in the Endothelium: Implications for Cancer Therapy

Figure 2

Endothelial PPARα has predominantly inhibitory actions on endothelial cell activation. The majority of studies so far indicate that PPARα activation induces (solid line) antiangiogenic factors, while reduces (broken line) proangiogenic factors, proinflammatory pathways, and procoagulant mediator release.