PTEN protein
signaling pathways. PTENā€™s lipid phosphatase activity dephosphorylates PIP3 to
PIP2 inhibiting PDK1-mediated Akt phosphorylation and downregulating Akt-mediated
cell survival. PTENā€™s protein phosphatase activity inhibits the phosphorylation
of FAK to prevent cell migration. PTENā€™s protein phosphatase activity also
dephosphorylates the SHC/SOS/GRB2
complex resulting in the decreased
phosphorylation of MAPK and inhibition of the cell cycle.