PPAR Research / 2008 / Article / Fig 2

Review Article

The Development of INT131 as a Selective PPAR 𝜸 Modulator: Approach to a Safer Insulin Sensitizer

Figure 2

PPARγ activation. Upon ligand binding, the nuclear receptor PPARγ associates with nuclear receptor RXR as well as with coactivators and corepressors which are present in a cell type and state specific pattern. This complex binds to PPAR response elements to enhance or repress gene transcription.