The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer
PPARγ activation. Upon ligand
binding, the nuclear receptor PPARγ associates with nuclear receptor RXR as
well as with coactivators and corepressors which are present in a cell type and
state specific pattern. This complex binds to PPAR response elements to enhance
or repress gene transcription.