Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats
Figure 6
Left ventricular expansion and ejection fraction in PD168 treated rats. (a) Left ventricular area (LVA) in systole and diastole; (b) Left ventricular internal dimension (LVID) in systole and diastole in normal male SD rats chronically treated with vehicle (VEH), PD168 at the dose of 10 mg/kgbody weight (PD-10) or 50 mg/kgbody weight (PD-50), (/treatment group). Means were compared using one-way ANOVA followed by Holm-Sidak test. Data are represented as means ± SEM. Different letters represent significant differences between the groups with “A” being highest mean and “AB" not different from “A" or “B" and so forth ( was considered significant).