Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

Figure 6

Left ventricular expansion and ejection fraction in PD168 treated rats. (a) Left ventricular area (LVA) in systole and diastole; (b) Left ventricular internal dimension (LVID) in systole and diastole in normal male SD rats chronically treated with vehicle (VEH), PD168 at the dose of 10 mg/kg⋅body weight (PD-10) or 50 mg/kg⋅body weight (PD-50), (𝑛=10/treatment group). Means were compared using one-way ANOVA followed by Holm-Sidak test. Data are represented as means ± SEM. Different letters represent significant differences between the groups with “A” being highest mean and “AB" not different from “A" or “B" and so forth (𝑝<0.05 was considered significant).

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