Effects of Chronic PPAR-Agonist Treatment on Cardiac Structure and Function, Blood Pressure, and Kidney in Healthy Sprague-Dawley Rats

Figure 9

(a) Absolute heart weight and heart-to-body-weight ratio; (b) Left ventricular area (LVA) in systole and diastole; and (c) Ejection fraction (EFA) in normal male SD rats chronically treated with vehicle (VEH) or rosiglitazone at the dose of 80 mg/kg⋅body weight (RGZ), (𝑛=10/treatment group). Data were represented as means ± SEM. Means were compared using unpaired t-test. *indicates a significant difference between the groups (𝑝<0.05).

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