Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs
Representation of keratinocyte differentiation and role of SULT2B1b-mediated cholesterol sulfonation . During formation of the epidermis, replicating basal keratinocytes give rise to progeny that move progressively upwards and pass through several histologically distinct strata. During this process, SULT2B1b expression becomes activated at approximately the level of the stratum granulosum. SULT2B1b-catalyzed cholesterol sulfonation produces cholesterol 3-sulfate that, in addition to its role as a lipid component of the outer barrier, functions as a signaling molecule that activates PKC and possibly ROR. These signaling events result in the induction of proteins that are involved in formation of the barrier. PPAR, PPAR, PPAR, and LXR have all been reported to positively regulate SULT2B1b expression in cultured keratinocytes.
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