TY - JOUR
A2 - Gregoire, Francine M.
AU - Tesse, Angela
AU - Andriantsitohaina, Ramaroson
AU - Ragot, Thierry
PY - 2009
DA - 2009/03/23
TI - PPAR Activity in Cardiovascular Diseases: A Potential Pharmacological Target
SP - 745821
VL - 2009
AB - Activation of peroxisome proliferator-activated receptors (PPARs), and particularly of PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus. PPARα and PPARγ anti-inflammatory, antiproliferative and antiangiogenic properties in cardiovascular cells were extensively clarified in a variety of in vitro and in vivo models. In contrast, the role of PPARδ in cardiovascular system is poorly understood. Prostacyclin, the predominant prostanoid released by vascular cells, is a putative endogenous agonist for PPARδ, but only recently PPARδ selective synthetic agonists were found, improving studies about the physiological and pathophysiological roles of PPARδ activation. Recent reports suggest that the PPARδ activation may play a pivotal role to regulate inflammation, apoptosis, and cell proliferation, suggesting that this transcriptional factor could become an interesting pharmacological target to regulate cardiovascular cell apoptosis, proliferation, inflammation, and metabolism.
SN - 1687-4757
UR - https://doi.org/10.1155/2009/745821
DO - 10.1155/2009/745821
JF - PPAR Research
PB - Hindawi Publishing Corporation
KW -
ER -