Fasting Upregulates PPAR𝛼 Target Genes in Brain and Influences Pituitary Hormone Expression in a PPAR𝛼 Dependent Manner

Figure 1

Effect of fasting or clofibrate treatment on mRNA concentration of acyl-CoA oxidase (ACO), carnitine palmitoyltransferases (CPT)-1A and -1C, medium chain acyl-CoA dehydrogenase (MCAD), long chain acyl-CoA dehydrogenase (LCAD), mitochondrial 3-hydroxy-3-methylglutaryl-(mHMG)-CoA synthase, and peroxisome proliferator-activated receptor (PPAR)-𝛼 in different brain areas of rats. All rats obtained a standard basal diet for 4 days. Animals of the fasting group were fasted 36 hours before killing. Rats of the clofibrate group were treated orally with 250 mg/kg of clofibrate per day. Values are means ±SD (𝑛=9). Symbols indicate significant difference from control rats (^∗𝑃<.05, ^∗∗𝑃<.001).

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