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PPAR Research
Volume 2010 (2010), Article ID 108632, 8 pages
http://dx.doi.org/10.1155/2010/108632
Review Article

Gastrointestinal Cytoprotection by PPAR 𝛾 Ligands

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan

Received 29 April 2010; Accepted 23 August 2010

Academic Editor: Paul Drew

Copyright © 2010 Yuji Naito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptor 𝛾 (PPAR 𝛾 ) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPAR 𝛾 has been implicated in the regulation of the immune response, particularly inflammation control, and has gained importance as a potential therapeutic target in the management of gastrointestinal inflammation. In the present paper, we present the current knowledge on the role of PPAR 𝛾 ligands in the gastrointestinal tract.