PPAR Research / 2010 / Article / Fig 1

Review Article

Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease

Figure 1

The isoflavones: generic 7-hydroxy-benzopyran-4-one ligands for PPARγ. Isoflavones have a B-ring aryl substituent in the 3-position and a Δ2-3 double bond. Common isoflavones are daidzein ( , , ), genistein ( ; ; ), formononetin ( ; ; ; ), and biochanin A ( ; ; ; ). The chemical library search also showed that the atom at position-3 in the B-ring can be either carbon or nitrogen.

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