Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease
Figure 1
The isoflavones: generic 7-hydroxy-benzopyran-4-one ligands for PPARγ. Isoflavones have a B-ring aryl substituent in the 3-position and a Δ2-3 double bond. Common isoflavones are daidzein (, , ), genistein (; ; ), formononetin (; ; ; ), and biochanin A (; ; ; ). The chemical library search also showed that the atom at position-3 in the B-ring can be either carbon or nitrogen.
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