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PPAR Research
Volume 2010, Article ID 169506, 12 pages
http://dx.doi.org/10.1155/2010/169506
Review Article

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark

Received 8 April 2010; Accepted 27 June 2010

Academic Editor: Chih-Hao Lee

Copyright © 2010 Anne Bugge and Susanne Mandrup. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR 𝛼 , 𝛽 / 𝛿 , and 𝛾 activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.