Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Figure 1

The PPAR A/B-domains potentiate transactivation of the highly subtype selective target genes. Illustration of the differential requirement for the PPAR A/B-domains in the transactivation of highly subtype selective and non-subtype selective target genes. The PPAR subtype specific target genes are generally expressed at very low levels in the absence of PPARs, but expression is dramatically increased upon introduction of full length exogenous PPAR. The activities of the PPAR A/B-domains are necessary to obtain this potent induction of the highly subtype specific target genes, presumably by facilitating recruitment and tethering of histone acetylase complexes (HATs) and the Mediator complex. Conversely, non-subtype selective PPAR target genes are usually already expressed at high levels in the absence of PPARs, and their expression levels are only increased by a few fold in response to ectopic PPAR expression. The PPAR A/B-domains appear to be dispensable for transactivation of this group of target genes.