Involvement of Fatty Acid Binding Protein 5 and PPAR𝛽/𝛿 in Prostate Cancer Cell Growth

Figure 5

A model for the cooperation between FABP5 and PPAR𝛽/𝛿 which enhances prostate cell survival and proliferation. Upon binding to a cognate ligand, FABP5 translocates to the nucleus where it directly delivers the ligand to its cognate nuclear receptor, PPAR𝛽/𝛿. Activation of PPAR𝛽/𝛿 results in upregulation of FABP5. A positive feedback loop is thus established: PPAR𝛽/𝛿 activation induces the expression of FABP5 which, in turn, enhances the transcriptional activity of the receptor. The FABP5/PPAR𝛽/𝛿 pathway induces the expression of PPAR𝛽/𝛿 target genes involved in cell survival, for example, PDK1, and growth and angiogenesis, for example, VEGF, and thus contributes to prostate cancer development.