Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha
Figure 4
Effects of gestational exposure to PFNA on relative liver weight of the wild-type (WT) and PPAR knockout (KO) nonpregnant adult female (a) dams (b) and pups (c) Measurements were taken on all individual adult females and on two pups per litter at weaning (i.e., 23 days after last dose or postnatal day 21). Data represent means or litter means SEM. Relative liver weight was calculated as the absolute liver weight/body weight for each data point. Relative liver weight was increased by PFNA exposure in both pregnant and non-pregnant adults and pups in all treated groups in the WT while only in the nonpregnant adult KO at 1.1 to 2 mg/kg and in the KO pup at 2.0 mg/kg. Significant differences were found by ANOVA, and differences between groups were found by Bonferroni’s test for multiple comparisons. Asterisks denote significant differences compared to controls (, ).
