Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha

Table 3

Liver and body weights (grams) of wild type and PPARα-KO adult females and pups at necropsy (PND 21) after exposure to PFNA on GD 1–18.

Strain	Dose (mg/kg/ day)	Adult females (NP)		Adult females (P)		Pups (sexes combined)
		Liver Weight	Body Weight	Liver Weight	Body Weighta	Liver Weight	Body Weight
	0	0.86±0.03	22.7±0.42	1.52±0.87	27.3±0.58	0.381±0.02	9.62±0.36
	0.83	1.49±0.04^∗∗	22.9±0.48	1.65±0.07	26.4±0.56	0.551±0.03^∗∗	9.79±0.30
WT	1.1	1.80±0.04^∗∗	24.0±0.43	1.91±0.10^∗	26.2±0.72	0.649±0.05^∗∗	10.34±0.61
	1.5	1.86±0.05^∗∗	23.0±0.56	2.24±0.05^∗∗	28.2±0.66	0.608±0.02^∗∗	9.47±0.23
	2.0	2.18±0.04^∗∗	24.2±0.36	2.51±0.07^∗∗	27.5±0.70	0.518±0.01^∗∗	7.56±0.42^∗∗
	0	0.99±0.04	24.8±0.74	1.88±0.06	29.1±0.32	0.417±0.01	9.35±0.19
	0.83	1.20±0.04	24.7±1.00	1.77±0.06	28.3±0.38	0.421±0.01	9.16±0.28
KO	1.1	1.17±0.07	23.2±0.54	2.02±0.05	29.6±0.40	0.429±0.02	9.18±0.26
	1.5	1.45±0.04^∗∗	23.8±0.41	1.74±0.16	26.2±1.32^∗	0.422±0.02	8.51±0.34
	2.0	1.53±0.04^∗∗	23.4±0.28	1.96±0.10	28.0±0.77	0.489±0.03	8.98±0.40

Values are means ± SEM.
Pup weights were on 2 pups per litter. NP: not pregnant; P: pregnant; WT: wild type; KO: PPARα knockout; Wt: weight.
NP includes those with full litter resorption and no weight gain; P includes those who gave birth whether pups were live or dead.
^a𝑃<.05 compared to NP females body weight. ^∗𝑃<.05, ^∗∗𝑃<.001 compared to controls within column and strain. See text for other comparisons.