PPAR Research / 2010 / Article / Tab 3

Research Article

Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha

Table 3

Liver and body weights (grams) of wild type and PPARα-KO adult females and pups at necropsy (PND 21) after exposure to PFNA on GD 1–18.

StrainDose (mg/kg/ day)Adult females (NP)Adult females (P)Pups (sexes combined)
Liver WeightBody WeightLiver WeightBody Weight Liver WeightBody Weight

0
0.83
WT1.1
1.5
2.0
0
0.83

KO1.1
1.5
2.0

Values are means SEM.
Pup weights were on 2 pups per litter. NP: not pregnant; P: pregnant; WT: wild type; KO: PPARα knockout; Wt: weight.
NP includes those with full litter resorption and no weight gain; P includes those who gave birth whether pups were live or dead.
compared to NP females body weight. , compared to controls within column and strain. See text for other comparisons.

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