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PPAR Research
Volume 2010, Article ID 345098, 6 pages
Review Article

Role of PPAR and Its Agonist in Renal Diseases

1Department of Medical Research, Tzu Chi General Hospital and Department of Pediatrics, Tzu Chi University, Hualien 970, Taiwan
2Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
3Graduate Institute of Clinical Medicine, Taipei Medical University and Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan
4Graduate Institute of Pharmacology and Toxicology, Tzu Chi University, 701 Chung Yang Road, Section 3, Hualien 970, Taiwan

Received 17 June 2010; Accepted 17 October 2010

Academic Editor: Béatrice Desvergne

Copyright © 2010 Ching-Feng Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Peroxisome proliferator-activated receptor (PPAR)- , a member of a large nuclear receptor superfamily, plays a major role in the regulation of lipid metabolism. Recently, PPAR activation has been shown to confer additional benefits on endothelial function, kidney function, and anti-inflammation, suggesting that PPAR agonists may be good candidates for treating acute renal failure. In clinical application, PPAR- activators, such as hypolipidemic drugs in fibric acid class, were proven to have therapeutic effects on metabolic syndrome and cardiovascular disease. This paper focuses on signaling pathways, ligand selectivity, and physio-pathological roles of PPAR in kidney diseases and the therapeutic utility of PPAR modulators in the treatment of diabetes and inflammation-induced nephropathy. Implication of new and more potent PPAR- activators could provide important insights into the overall benefits of activating PPAR- clinically for the treatment of dyslipidemia and the prevention of diabetic or inflammation-induced nephropathy in the future.