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PPAR Research
Volume 2010 (2010), Article ID 417646, 7 pages
http://dx.doi.org/10.1155/2010/417646
Review Article

Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3

Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan

Received 26 May 2010; Accepted 14 July 2010

Academic Editor: Tianxin Yang

Copyright © 2010 Kenneth K. Wu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Peroxisome proliferator-activated receptors (PPARs) were reported to prevent cells from stress-induced apoptosis and protect tissues against ischemia-reperfusion injury. The underlying transcriptional mechanism is unclear. Recent reports indicate that the antiapoptotic actions of ligand-activated PPAR and PPAR are mediated through enhanced binding of PPAR to the promoter of 14-3-3 and upregulation of 14-3-3 expression. We propose that ligand-activated PPAR exerts its anti-apoptotic actions via the identical pathway. The PPAR to 14-3-3 transcriptional axis plays an important role in protection of cell and tissue integrity and is a target for drug discovery.