Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2010, Article ID 483958, 9 pages
http://dx.doi.org/10.1155/2010/483958
Review Article

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

1Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan
2Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011, Japan
3Laboratory of Food Nutrition, Division of Applied Biological Chemistry, Graduate School of Horticulture, Chiba University, 648 Matsudo, Chiba 271-8510, Japan

Received 8 February 2010; Accepted 23 March 2010

Academic Editor: Harry Martin

Copyright © 2010 Tsuyoshi Goto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [68 citations]

The following is the list of published articles that have cited the current article.

  • Saswati Mahapatra, R. Jeffrey Karnes, Michael W. Holmes, Charles Y. F. Young, John C. Cheville, Manish Kohli, Eric W. Klee, Donald J. Tindall, and Krishna Vanaja Donkena, “Novel Molecular Targets of Azadirachta indica Associated with Inhibition of Tumor Growth in Prostate Cancer,” Aaps Journal, vol. 13, no. 3, pp. 365–377, 2011. View at Publisher · View at Google Scholar
  • Bokyung Sung, Sahdeo Prasad, Vivek R. Yadav, Afsaneh Lavasanifar, and Bharat B. Aggarwal, “Cancer and diet: How are they related?,” Free Radical Research, vol. 45, no. 8, pp. 864–879, 2011. View at Publisher · View at Google Scholar
  • Rino Kimura, Nobuyuki Takahashi, Kaeko Murota, Yuko Yamada, Saori Niiya, Noriyuki Kanzaki, Yoko Murakami, Tatsuya Moriyama, Tsuyoshi Goto, and Teruo Kawada, “Activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes,” Biochemical And Biophysical Research Communications, vol. 410, no. 1, pp. 1–6, 2011. View at Publisher · View at Google Scholar
  • Marta González-Castejón, and Arantxa Rodriguez-Casado, “Dietary phytochemicals and their potential effects on obesity: A review,” Pharmacological Research, vol. 64, no. 5, pp. 438–455, 2011. View at Publisher · View at Google Scholar
  • Nandipha Mnonopi, Ruby-Ann Levendal, Michael T. Davies-Coleman, and Carminita L. Frost, “The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts,” Journal of Ethnopharmacology, vol. 138, no. 1, pp. 67–75, 2011. View at Publisher · View at Google Scholar
  • Yaoyao Jia, Muhammad Javidul Haque Bhuiyan, Hee-jin Jun, Ji Hae Lee, Minh Hien Hoang, Hak-Ju Lee, Nahyun Kim, Dongho Lee, Kwang Yeon Hwang, Bang Yeon Hwang, Dal-Woong Choi, and Sung-Joon Lee, “Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism,” Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 19, pp. 5876–5880, 2011. View at Publisher · View at Google Scholar
  • Kirsi Bromann, Mervi Toivari, Kaarina Viljanen, Anu Vuoristo, Laura Ruohonen, and Tiina Nakari-Setala, “Identification and Characterization of a Novel Diterpene Gene Cluster in Aspergillus nidulans,” Plos One, vol. 7, no. 4, 2012. View at Publisher · View at Google Scholar
  • Angela Zampella, Maria Valeria D'Auria, and Valentina Sepe, “Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications,” Current Topics In Medicinal Chemistry, vol. 12, no. 6, pp. 637–669, 2012. View at Publisher · View at Google Scholar
  • Tsuyoshi Goto, Nobuyuki Takahashi, Sota Kato, Young-Il Kim, Tatsuya Kusudo, Aki Taimatsu, Kahori Egawa, Min-Sook Kang, Takuro Hiramatsu, Tomoya Sakamoto, Taku Uemura, Shizuka Hirai, Misato Kobayashi, Fumihiko Horio, and Teruo Kawada, “Bixin Activates PPARα and Improves Obesity-Induced Abnormalities of Carbohydrate and Lipid Metabolism in Mice,” Journal of Agricultural and Food Chemistry, vol. 60, no. 48, pp. 11952–11958, 2012. View at Publisher · View at Google Scholar
  • Tsuyoshi Goto, Young-Il Kim, Nobuyuki Takahashi, and Teruo Kawada, “Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors,” Molecular Nutrition & Food Research, vol. 57, no. 1, pp. 20–33, 2012. View at Publisher · View at Google Scholar
  • Hayato Maeda, Mao Yamazaki, and Yohtaro Katagata, “Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells,” Experimental And Therapeutic Medicine, vol. 3, no. 1, pp. 49–52, 2012. View at Publisher · View at Google Scholar
  • Ramasamy S Annadurai, Vasanthan Jayakumar, Raja C Mugasimangalam, Mohan AVSK Katta, Sanchita Anand, Sreeja Gopinathan, Santosh Sarma, Sunjay Fernandes, Nandita Mullapudi, S Murugesan, and Sudha Rao, “Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties,” BMC Genomics, vol. 13, no. 1, pp. 663, 2012. View at Publisher · View at Google Scholar
  • Swati Singh, Veda P Pandey, Huma Naaz, Priyanka Singh, and Upendra N. Dwivedi, “Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: Implications in drug designing and development,” Computers in Biology and Medicine, vol. 43, no. 6, pp. 744–750, 2013. View at Publisher · View at Google Scholar
  • Anwar Shahzad, Arjumend Shaheen, Aastha Sahai, M. Imran Kozgar, and Shiwali Sharmapp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Carani Venkatraman Anuradha, “ Phytochemicals targeting genes relevant for type 2 diabetes 1 ,” Canadian Journal of Physiology and Pharmacology, vol. 91, no. 6, pp. 397–411, 2013. View at Publisher · View at Google Scholar
  • Swapan K Ghosh, and Roshni Roy Chowdhury, “Synthetic adjuvants for vaccine formulations: phytol derivatives,” Expert Opinion on Drug Delivery, vol. 10, no. 4, pp. 437–450, 2013. View at Publisher · View at Google Scholar
  • Linda Gijsbers, Henriëtte D. L. M. van Eekelen, Laura H. J. de Haan, Jorik M. Swier, Nienke L. Heijink, Samantha K. Kloet, Hai-Yen Man, Arnaud G. Bovy, Jaap Keijer, Jac M. M. J. G. Aarts, Bart van der Burg, and Ivonne M. C. M. Rietjens, “ Induction of Peroxisome Proliferator-Activated Receptor γ (PPARγ)-Mediated Gene Expression by Tomato ( Solanum lycopersicum L.) Extracts ,” Journal of Agricultural and Food Chemistry, vol. 61, no. 14, pp. 3419–3427, 2013. View at Publisher · View at Google Scholar
  • Tsuyoshi Goto, Ayaka Mori, and Satoshi Nagaoka, “Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells,” Molecular Nutrition & Food Research, 2013. View at Publisher · View at Google Scholar
  • O. B. Kazakova, I. E. Smirnova, H. Do Tkhi Tkhu, Tt Tkhankh Tra Nguen, G. N. Apryshko, O. S. Zhukova, N. I. Medvedeva, T. I. Nazyrov, E. V. Tret'yakova, I. V. Chudov, A. F. Ismagilova, K. Yu Suponitsky, D. V. Kazakov, F. E. Safarov, and G. A. Tolstikov, “Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid,” Russian Journal Of Bioorganic Chemistry, vol. 39, no. 2, pp. 202–210, 2013. View at Publisher · View at Google Scholar
  • Hayato Maeda, Mao Yamazaki, and Yohtaro Katagata, “Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells,” Bioscience Biotechnology And Biochemistry, vol. 77, no. 3, pp. 482–486, 2013. View at Publisher · View at Google Scholar
  • Lorenza Putignani, Ornella Massa, and Anna Alisi, “Engineered Escherichia coli as new source of flavonoids and terpenoids,” Food Research International, 2013. View at Publisher · View at Google Scholar
  • Lærke Münter Lassen, Agnieszka Zygadlo Nielsen, Bibi Ziersen, Thiyagarajan Gnanasekaran, Birger Lindberg Møller, and Poul Erik Jensen, “Redirecting Photosynthetic Electron Flow into Light-Driven Synthesis of Alternative Products Including High-Value Bioactive Natural Compounds,” ACS Synthetic Biology, pp. 131223102918001, 2013. View at Publisher · View at Google Scholar
  • Baishakhi Dey, and Analava Mitra, “Chemo-profiling of eucalyptus and study of its hypoglycemic potential.,” World journal of diabetes, vol. 4, no. 5, pp. 170–6, 2013. View at Publisher · View at Google Scholar
  • Min He, Jun Yan, Dongsheng Cao, Shao Liu, Chenxi Zhao, Yizeng Liang, Yaping Li, and Zhimin Zhang, “Identification of terpenoids from Ephedra combining with accurate mass and in-silico retention indices,” Talanta, vol. 103, pp. 116–122, 2013. View at Publisher · View at Google Scholar
  • Palazzo, Colella, Vizzarri, Casamassima, D'Alessandro, and Corino, “The effects of lemon verbena (Lippia citriodora) verbascoside on the productive performance, plasma oxidative status, and some blood metabolites in suckling lambs,” Journal of Animal and Feed Sciences, vol. 22, no. 3, pp. 204–212, 2013. View at Publisher · View at Google Scholar
  • Hayato Maeda, Shuuichi Saito, Nozomi Nakamura, and Takashi Maoka, “Paprika Pigments Attenuate Obesity-Induced Inflammation in 3T3-L1 Adipocytes,” ISRN Inflammation, vol. 2013, pp. 1–9, 2013. View at Publisher · View at Google Scholar
  • Nizam Uddin, Md. Rakib Hasan, Md. Monir Hossain, Arjyabrata Sarker, A.H.M. Nazmul Hasan, A.F.M. Mahmudul Islam, Mohd. Motaher H. Chowdhury, and Md. Sohel Rana, “In vitro α–amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus macroptera Montr. fruit,” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 6, pp. 473–479, 2014. View at Publisher · View at Google Scholar
  • Natasha Beukes, Ruby-Ann Levendal, and Carminita L. Frost, “Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders,” Journal of Pharmacy and Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Mohamed Eddouks, Amina Bidi, Bachir El Bouhali, Lhoussain Hajji, and Naoufel Ali Zeggwagh, “Antidiabetic plants improving insulin sensitivity,” Journal of Pharmacy and Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Baishakhi Dey, Analava Mitra, Prakash Katakam, and Rajeev K Singla, “Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays.,” World journal of diabetes, vol. 5, no. 2, pp. 209–18, 2014. View at Publisher · View at Google Scholar
  • Librado A Santiago, and Anna Beatriz R Mayor, “Lupeol: An antioxidant triterpene in Ficus pseudopalma Blanco (Moraceae),” Asian Pacific Journal of Tropical Biomedicine, vol. 4, no. 2, pp. 109–118, 2014. View at Publisher · View at Google Scholar
  • Lærke Münter Lassen, Bibi Ziersen, Agnieszka Zygadlo Nielsen, Thiyagarajan Gnanasekaran, Birger Lindberg Møller, and Poul Erik Jensen, “Redirecting photosynthetic electron flow into light-driven synthesis of alternative products including high-value bioactive natural compounds,” ACS Synthetic Biology, vol. 3, no. 1, pp. 1–12, 2014. View at Publisher · View at Google Scholar
  • H. S. Mun, S. T. Ahmed, J. A. Hwang, Y. J. Kim, and C. J. Yang, “Evaluation of fermented Alisma canaliculatum with probiotics as potential feed additives for finishing Hanwoo (Bos taurus coreanae) steers,” Animal Production Science, vol. 54, no. 8, pp. 1064, 2014. View at Publisher · View at Google Scholar
  • Miguel Roehrs, Cassieli Gehlen Figueiredo, Mariane Magalhães Zanchi, Guilherme Vargas Bochi, Rafael Noal Moresco, Andréia Quatrin, Sabrina Somacal, Lisiane Conte, and Tatiana Emanuelli, “Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats,” International Journal of Endocrinology, vol. 2014, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Zulkhairi Amom, “Antioxidant Activity Characterization, Phytochemical Screening, and Proximate Analysis of Cermela Hutan (Phyllanthus gomphocarpus Hook. F) Roots and Leaves,” Medical Science Monitor Basic Research, vol. 20, pp. 170–175, 2014. View at Publisher · View at Google Scholar
  • Élida Batista Vieira De Sousa, and Hemerson Iury Ferreira Magalhãespp. 135–174, 2015. View at Publisher · View at Google Scholar
  • Wing Ho, “Therapeutic Benefits of Phytochemicals,” Active Phytochemicals from Chinese Herbal Medicines, pp. 65–86, 2015. View at Publisher · View at Google Scholar
  • Yanrong Lv, Ibrahim I Tahir, and Marie E Olsson, “ Factors affecting the content of the ursolic and oleanolic acid in apple peel: influence of cultivars, sun exposure, storage conditions, bruising and Penicillium expansum infection ,” Journal of the Science of Food and Agriculture, 2015. View at Publisher · View at Google Scholar
  • Nashwa A. El-Shinnawy, “The therapeutic applications of celery oil seed extract on the plasticizer di(2-ethylhexyl) phthalate toxicity,” Toxicology And Industrial Health, vol. 31, no. 4, pp. 355–366, 2015. View at Publisher · View at Google Scholar
  • Xiu-Bin Sun, Shao-Mei Wang, Tao Li, and Yong-qing Yang, “Anticancer Activity of Linalool Terpenoid: Apoptosis Induction and Cell Cycle Arrest in Prostate Cancer Cells,” Tropical Journal Of Pharmaceutical Research, vol. 14, no. 4, pp. 619–625, 2015. View at Publisher · View at Google Scholar
  • Prakash Katakam, Tanmoy Samanta, Dilip Kumar Kushwaha, Rohit Gundamaraju, Analava Mitra, Baishakhi De, Koushik Bhandari, and Rajeev K. Singla, “Chemometrics Optimized Extraction Procedures, Phytosynergistic Blending and in vitro Screening of Natural Enzyme Inhibitors Amongst Leaves of Tulsi, B,” Pharmacognosy Magazine, vol. 11, no. 44, pp. S522–S532, 2015. View at Publisher · View at Google Scholar
  • L. F. De Filippis, “Plant secondary metabolites,” Plant-Environment Interaction, pp. 263–299, 2015. View at Publisher · View at Google Scholar
  • Sahil J. Somani, Ketan P. Modi, Anuradha S. Majumdar, and Bhakti N. Sadarani, “Phytochemicals and Their Potential Usefulness in Inflammatory Bowel Disease,” Phytotherapy Research, 2015. View at Publisher · View at Google Scholar
  • Kakali Mukherjee, Rajarshi Biswas, Sushil K. Chaudhary, and Pulok K. Mukherjee, “Botanicals as Medicinal Food and Their Effects against Obesity,” Evidence-Based Validation of Herbal Medicine, pp. 373–403, 2015. View at Publisher · View at Google Scholar
  • Daniel Załuski, Łukasz Cieśla, and Zbigniew Janeczko, “The Structure–Activity Relationships of Plant Secondary Metabolites with Antimicrobial, Free Radical Scavenging and Inhibitory Activity toward Selected Enzymes,” vol. 45, pp. 217–249, 2015. View at Publisher · View at Google Scholar
  • Tahir, Olsson, and Lv, “Influence of rootstock, harvest time, and storage conditions on triterpene content of apple peel,” Acta Horticulturae, vol. 1120, pp. 405–408, 2016. View at Publisher · View at Google Scholar
  • Mohamed El Sayed Abeer, “Leaves of Schinus polygamous (Cav.) Cabrera (Anacardiaceae) are a potential source of hepatoprotective and antioxidant phytochemicals,” Journal of Medicinal Plants Research, vol. 10, no. 17, pp. 223–231, 2016. View at Publisher · View at Google Scholar
  • Haixia Yang, Lei Xiao, and Nanping Wang, “ Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions ,” Journal of Diabetes, 2016. View at Publisher · View at Google Scholar
  • Shajrul Amin, Showkat Ahmad Ganie, Khalid Bashir Dar, Aashiq Hussain Bhat, Akbar Masood, and Mohammad Afzal Zargar, “Inflammation: A multidimensional insight on natural anti-inflammatory therapeutic compounds,” Current Medicinal Chemistry, vol. 23, no. 33, pp. 3775–3800, 2016. View at Publisher · View at Google Scholar
  • Shahpour Khangholi, Fadzilah Adibah Abdul Majid, Najat Jabbar Ahmed Berwary, Farediah Ahmad, and Ramlan Bin Abd Aziz, “The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition,” Planta Medica, vol. 82, no. 1-2, pp. 32–45, 2016. View at Publisher · View at Google Scholar
  • N.A. Raut, P.W. Dhore, S.D. Saoji, and D.M. Kokare, “Selected Bioactive Natural Products for Diabetes Mellitus,” vol. 48, pp. 287–322, 2016. View at Publisher · View at Google Scholar
  • Miguel Roehrs, Lisiane Conte, Dariane Trivisiol da Silva, Thiago Duarte, Luana Haselein Maurer, José Antonio Mainardi, Rafael Noal Moresco, Sabrina Somacal, and Tatiana Emanuelli, “Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects,” Food Research International, 2017. View at Publisher · View at Google Scholar
  • Daniela Rigano, Carmina Sirignano, and Orazio Taglialatela-Scafati, “The potential of natural products for targeting PPAR ?,” Acta Pharmaceutica Sinica B, 2017. View at Publisher · View at Google Scholar
  • Siba Shanak, Bashar Saad, Hilal Zaid, and Sleman Kadanpp. 1–257, 2017. View at Publisher · View at Google Scholar
  • Bashar Saad, Hilal Zaid, Siba Shanak, Sleman Kadan, Bashar Saad, Hilal Zaid, Siba Shanak, and Sleman Kadan, “Prevention and Treatment of Obesity-Related Diseases by Diet and Medicinal Plants,” Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals, pp. 95–128, 2017. View at Publisher · View at Google Scholar
  • Bashar Saad, Hilal Zaid, Siba Shanak, Sleman Kadan, Bashar Saad, Hilal Zaid, Siba Shanak, and Sleman Kadan, “Herbal-Derived Anti-obesity Compounds and Their Action Mechanisms,” Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals, pp. 129–144, 2017. View at Publisher · View at Google Scholar
  • Mohammad Reza Morshedloo, Lyle E. Craker, Alireza Salami, Vahideh Nazeri, Hyunkyu Sang, and Filippo Maggi, “Effect of prolonged water stress on essential oil content, compositions and gene expression patterns of mono- and sesquiterpene synthesis in two oregano (Origanum vulgare L.) subspecies,” Plant Physiology and Biochemistry, vol. 111, pp. 119–128, 2017. View at Publisher · View at Google Scholar
  • Seon Young Park, Dongsoo Yang, Shin Hee Ha, and Sang Yup Lee, “Metabolic Engineering of Microorganisms for the Production of Natural Compounds,” Advanced Biosystems, pp. 1700190, 2017. View at Publisher · View at Google Scholar
  • Hui Teng, Sivapragasam Gothai, Palanisamy Arulselvan, and Lei Chen, “Dietary triterpenes in the treatment of type 2 diabetes: To date,” Trends in Food Science & Technology, 2017. View at Publisher · View at Google Scholar
  • Tatiana Emanuelli, Paula Rossini Augusti, and Miguel Roehrs, “Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes,” Fruit and Vegetable Phytochemicals, pp. 347–385, 2017. View at Publisher · View at Google Scholar
  • Peng Yew, Yau Lim, and Wai Lee, “Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura,” Pharmacognosy Research, vol. 9, no. 4, pp. 366–371, 2017. View at Publisher · View at Google Scholar
  • Gangadharappa, Mruthunjaya, and Rudra Pratap Singh, “Cuminum cyminum -A popular spice: An updated review,” Pharmacognosy Journal, vol. 9, no. 3, pp. 292–301, 2017. View at Publisher · View at Google Scholar
  • Beverly A.S. Reyes, Elsa C. Dufourt, Jennifer Ross, Michael J. Warner, Neil C. Tanquilut, and Albert B. Leung, “Selected Phyto and Marine Bioactive Compounds: Alternatives for the Treatment of Type 2 Diabetes,” vol. 55, pp. 111–143, 2017. View at Publisher · View at Google Scholar
  • Jeffrey J. Czajka, Justin A. Nathenson, Veronica T. Benites, Edward E. K. Baidoo, Qianshun Cheng, Yechun Wang, and Yinjie J. Tang, “Engineering the oleaginous yeast Yarrowia lipolytica to produce the aroma compound β-ionone,” Microbial Cell Factories, vol. 17, no. 1, 2018. View at Publisher · View at Google Scholar
  • Seul Gi Lee, Jin Soo Kim, Kyoungjin Min, Taeg Kyu Kwon, and Ju-Ock Nam, “Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway,” Chemico-Biological Interactions, 2018. View at Publisher · View at Google Scholar
  • Elisa Di Stefano, Teresa Oliviero, and Chibuike C. Udenigwe, “Functional significance and structure-activity relationship of food-derived α-glucosidase inhibitors,” Current Opinion in Food Science, 2018. View at Publisher · View at Google Scholar
  • Teruo Kawada, “Food-derived regulatory factors against obesity and metabolic syndrome,” Bioscience, Biotechnology, and Biochemistry, pp. 1–7, 2018. View at Publisher · View at Google Scholar
  • Swati Singh, Veda P. Pandey, Manika Awasthi, and Upendra N. Dwivedi, “Natural products as anticancerous therapeutic molecules with special reference to enzymatic targets topoisomerase, COX, LOX and Aromatase,” Current Protein and Peptide Science, vol. 19, no. 3, pp. 238–274, 2018. View at Publisher · View at Google Scholar