TY - JOUR
A2 - Ko, Joshua K.
AU - Yoke Yin, Chia
AU - So Ha, Ton
AU - Abdul Kadir, Khalid
PY - 2010
DA - 2009/11/16
TI - Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPAR), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats
SP - 530265
VL - 2010
AB - Studies on ligand binding potential of glycyrrhizic acid, a potential agonist to PPARγ, displayed encouraging results in amelioration of metabolic syndrome. The regulation of gene cassettes by PPARγ affects glucose homeostasis, lipid, lipoprotein metabolism and adipogenesis. This study was performed to determine the effects of GA on total PPARγ and LPL expression levels, lipid parameters and HOMA-IR. Oral administration of 100 mg/kg GA for 24 hours resulted in an increase in insulin sensitivity with decreases in blood glucose, serum insulin and HOMA-IR. Improvement in serum lipid parameters was also observed with a decrease in triacylglycerol, total cholesterol and LDL-cholesterol and an elevation in HDL-cholesterol. GA administration also resulted in up-regulation of total PPARγ and LPL expression levels in the visceral and subcutaneous adipose tissues, abdominal and quadriceps femoris muscles, as well as liver and kidney, with a significant up-regulation only in the visceral adipose tissue, abdominal and quadriceps femoris muscles. Thus, oral administration of 100 mg/kg GA for 24 hours improved insulin sensitivity and lipid profiles and induced upregulation of total PPARγ and LPL expression levels in all studied tissues.
SN - 1687-4757
UR - https://doi.org/10.1155/2010/530265
DO - 10.1155/2010/530265
JF - PPAR Research
PB - Hindawi Publishing Corporation
KW -
ER -