Table of Contents Author Guidelines Submit a Manuscript
PPAR Research
Volume 2010, Article ID 549101, 10 pages
http://dx.doi.org/10.1155/2010/549101
Review Article

AMPK-Dependent Metabolic Regulation by PPAR Agonists

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea

Received 22 April 2010; Accepted 25 June 2010

Academic Editor: Howard Glauert

Copyright © 2010 Woo Hyung Lee and Sang Geon Kim. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [27 citations]

The following is the list of published articles that have cited the current article.

  • Omneya Galal, Julia Podlogar, and Eugen J. Verspohl, “Impact of ADMA (asymmetric dimethylarginine) on physiology with respect to diabetes mellitus and respiratory system BEAS-2B cells (human bronchial epithelial cells),” Journal of Pharmacy and Pharmacology, vol. 65, no. 2, pp. 253–263, 2012. View at Publisher · View at Google Scholar
  • Xilin Yang, Wing-Yee So, Ronald C.W. Ma, Linda W.L. Yu, Alice P.S. Kong, Heung Man Lee, Gang Xu, Risa Ozaki, Gary T.C. Ko, and Juliana C.N. Chan, “Use of thiazolidinedione and cancer risk in Type 2 diabetes: The Hong Kong diabetes registry,” Diabetes Research and Clinical Practice, vol. 97, no. 1, pp. e13–e17, 2012. View at Publisher · View at Google Scholar
  • J. Jeyabalan, M. Shah, B. Viollet, and C. Chenu, “AMP-activated protein kinase pathway and bone metabolism,” Journal of Endocrinology, vol. 212, no. 3, pp. 277–290, 2012. View at Publisher · View at Google Scholar
  • Navin Viswakarma, Yuzhi Jia, Liang Bai, Qian Gao, Bingliang Lin, Xiaohong Zhang, Parimal Misra, Ajay Rana, Sanjay Jain, Frank J. Gonzalez, Yi-Jun Zhu, Bayar Thimmapaya, and Janardan K. Reddy, “The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase,” Journal of Biological Chemistry, vol. 288, no. 39, pp. 27898–27911, 2013. View at Publisher · View at Google Scholar
  • David S. Fedson, “Treating Influenza with Statins and Other Immunomodulatory Agents,” Antiviral Research, 2013. View at Publisher · View at Google Scholar
  • Joseph Barbi, Drew Pardoll, and Fan Pan, “Metabolic control of the Treg/Th17 axis,” Immunological Reviews, vol. 252, no. 1, pp. 52–77, 2013. View at Publisher · View at Google Scholar
  • Man-Jung Hsu, Dai-Jung Chung, Chau-Jong Wang, Jia-Jen Chang, Yun-Ching Chang, and Hui-Pei Huang, “Mulberry Anthocyanins Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance,” Journal Of Agricultural And Food Chemistry, vol. 61, no. 25, pp. 6069–6076, 2013. View at Publisher · View at Google Scholar
  • Sonia Fernandez-Veledo, Ana Vazquez-Carballo, Joan Vendrell, Rocio Vila-Bedmar, and Victoria Ceperuelo-Mallafre, “Role of energy- and nutrient-sensing kinases AMP-activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in Adipocyte Differentiation,” Iubmb Life, vol. 65, no. 7, pp. 572–583, 2013. View at Publisher · View at Google Scholar
  • Jing-Ru Weng, Li-Yuan Bai, Chang-Fang Chiu, Jing-Lan Hu, Shih-Jiuan Chiu, and Chia-Yung Wu, “Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–12, 2013. View at Publisher · View at Google Scholar
  • Kevin Man, and Axel Kallies, “Synchronizing transcriptional control of T cell metabolism and function,” Nature Reviews Immunology, 2015. View at Publisher · View at Google Scholar
  • Mohamed H. Noureldein, Rania S. Abd El-Razek, Mohamed H. El-Hefnawy, and Hala O. El-Mesallamy, “Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis,” Diabetes Research and Clinical Practice, 2015. View at Publisher · View at Google Scholar
  • Mehdi Yousefi, Ali Akbar Movassaghpour, Karim Shamsasenjan, Ghasem Ghalamfarsa, Sanam Sadreddini, Farhad Jadidi-Niaragh, and Mohammad Hojjat-Farsangi, “The skewed balance between Tregs and Th17 in chronic lymphocytic leukemia,” Future Oncology, vol. 11, no. 10, pp. 1567–1582, 2015. View at Publisher · View at Google Scholar
  • Sonja Lieber, Frithjof Scheer, Florian Finkernagel, Wolfgang Meissner, Gavin Giehl, Cornelia Brendel, Wibke E. Diederich, Sabine Mueller-Bruesselbach, and Rolf Mueller, “The Inverse Agonist DG172 Triggers a PPAR beta/delta-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation,” Molecular Pharmacology, vol. 87, no. 2, pp. 162–173, 2015. View at Publisher · View at Google Scholar
  • Xuemei Liu, Jiamei Lian, Chang-Hua Hu, and Chao Deng, “Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα-dependent pathways,” Pharmacological Research, vol. 100, pp. 36–46, 2015. View at Publisher · View at Google Scholar
  • Georgios Liappas, Guadalupe Tirma Gónzalez-Mateo, Pedro Majano, José Antonio Sánchez- Tomero, Marta Ruiz-Ortega, Raquel Rodrigues Díez, Pilar Martín, Raquel Sanchez-Díaz, Rafael Selgas, Manuel López-Cabrera, and Abelardo Aguilera Peralta, “T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage,” BioMed Research International, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Nawal M. Al-Rasheed, Nouf M. Al-Rasheed, Hala A. Attia, Maha A. Al-Amin, Hanaa N. Al-Ajmi, Iman H. Hasan, Raeesa A. Mohamad, and Nasr A. Sinjilawi, “Renoprotective Effects of Fenofibrate via Modulation of LKB1/AMPK mRNA Expression and Endothelial Dysfunction in a Rat Model of Diabetic Nephropathy,” Pharmacology, vol. 95, no. 5-6, pp. 229–239, 2015. View at Publisher · View at Google Scholar
  • Antero Salminen, Anu Kauppinen, and Kai Kaarniranta, “FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process,” Journal of Molecular Medicine, 2016. View at Publisher · View at Google Scholar
  • Torsten Schröder, David Kucharczyk, Florian Bär, René Pagel, Stefanie Derer, Sebastian Torben Jendrek, Annika Sünderhauf, Ann-Kathrin Brethack, Misa Hirose, Steffen Möller, Axel Künstner, Julia Bischof, Imke Weyers, Jörg Heeren, Dirk Koczan, Sebastian Michael Schmid, Senad Divanovic, Daniel A. Giles, Jerzy Adamski, Klaus Fellermann, Hendrik Lehnert, Jörg Köhl, Saleh Ibrahim, and Christian Sina, “Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis,” Molecular Metabolism, 2016. View at Publisher · View at Google Scholar
  • Yafei Sun, Tian Tian, Juan Gao, Xiaoqian Liu, Huiqing Hou, Runjing Cao, Bin Li, Moyuan Quan, and Li Guo, “Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice,” Journal of Neuroimmunology, 2016. View at Publisher · View at Google Scholar
  • Paolo D. A. Vignali, Joseph Barbi, and Fan Pan, “Metabolic Regulation of T Cell Immunity,” Immune Metabolism in Health and Tumor, vol. 1011, pp. 87–130, 2017. View at Publisher · View at Google Scholar
  • Edmond Differding, “The Drug Discovery and Development Industry in India-Two Decades of Proprietary Small-Molecule R&D,” ChemMedChem, 2017. View at Publisher · View at Google Scholar
  • Dong-Woo Lim, Shambhunath Bose, Jing-Hua Wang, Han Seok Choi, Young-Mi Kim, Young-Won Chin, Song-Hee Jeon, Jai-Eun Kim, and Hojun Kim, “Modified SJH alleviates FFAs-induced hepatic steatosis through leptin signaling pathways,” Scientific Reports, vol. 7, pp. 45425, 2017. View at Publisher · View at Google Scholar
  • Barkhordari, Shahouzehi, Aminizadeh, and Masoumi-Ardakani, “Effect of L-carnitine administration on se rum insulin and adiponect in levels, and AMPK, APPL1 and PPARγ gene express ion in STZ-induced diabetic rat liver,” Ukrainian Biochemical Journal, vol. 89, no. 6, pp. 48–55, 2017. View at Publisher · View at Google Scholar
  • Seong Jin Kim, Hwi Young Yun, Pusoon Chun, Hyung Ryong Moon, Hae Young Chung, Eun Kyeong Lee, Ki Wung Chung, Kyoung Mi Moon, Hye Jin An, Ye Ra Kim, Byung Pal Yu, Bonggi Lee, Dae Hyun Kim, Min Hi Park, Hyoung Oh Jeong, and Sung Min Kim, “Physiological characterization of a novel PPAR pan agonist, 2-(4-(5,6-methylenedioxybenzo[d]thiazol-2-yl)-2-methylphenoxy)- 2-methylpropanoic acid (MHY2013),” Oncotarget, vol. 8, no. 10, pp. 16912–16924, 2017. View at Publisher · View at Google Scholar
  • Mervat A. Ahmed, Mona A. Mohamed, Laila A. Rashed, Sohaier A. Abd Elbast, and Elham A. Ahmed, “Rice Bran Oil Improves Insulin Resistance by Affecting the Expression of Antioxidants and Lipid-Regulatory Genes,” Lipids, 2018. View at Publisher · View at Google Scholar
  • Rou-Ling Cho, Wei-Ning Lin, Chen-yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chih-Chung Lin, and Chuen-Mao Yang, “Heme oxygenase-1 induction by rosiglitazone via PKCα/AMPKα/p38 MAPKα/SIRT1/PPARγ pathway suppresses lipopolysaccharide-mediated pulmonary inflammation,” Biochemical Pharmacology, 2018. View at Publisher · View at Google Scholar
  • Bryan Tungland, “Short-Chain Fatty Acid Production and Functional Aspects on Host Metabolism,” Human Microbiota in Health and Disease, pp. 37–106, 2018. View at Publisher · View at Google Scholar