Influence of PPARα on hepatic glycogen metabolism. Synthesis (blue arrows) and breakdown of glycogen (purple arrows) are depicted, together with the regulatory effects of PPAR. Direct transcriptional influence is presented as a full green arrow. An effect that was only observed in PPAR mice is depicted as a dark green dashed arrow. Genes in which a PPRE was identified, but no in vivo activation by PPARα was observed are presented with a dark green dotted arrow. A suppressive effect of PPAR is shown with a red mark. G6Pase: glucose-6-phosphatase; GLUT2: glucose transporter 2; GSK-3: glycogen synthase kinase 3; UDP-glucose: uridine diphosphate glucose.
