PPAR𝛼 in Obesity: Sex Difference and Estrogen Involvement

Figure 1

Schematic structure of the functional domains of nuclear receptors. The activation domains AF-1 and AF-2 are located at the N-terminal and C-terminal regions, respectively. C domain is a highly conserved DNA-binding domain. D domain is a highly flexible hinge region. E/E domain is responsible for ligand-binding and converting nuclear receptors to active forms that bind DNA. Adapted from [29].