PPAR Research / 2010 / Article / Fig 5

Review Article

PPAR in Obesity: Sex Difference and Estrogen Involvement

Figure 5

Differential regulation of body weight gain (a) and PPAR target gene expression (b) by fenofibrate depending on the presence of ovaries. Female sham-operated (Sham) and ovariectomized (OVX) mice received a low fat, high fat, or fenofibrate-supplemented (FF; 0.05% w/w) high fat diet for 13 weeks. Body weights at the end of the treatment period are significantly different not only when comparing the low fat group to either the high fat or high fat plus FF groups in female Sham mice, but also when comparing the high fat group to either the low fat or high fat plus FF groups in female OVX mice. Significantly different versus the high fat group, Significantly different versus the Sham group, ACOX: acyl-CoA oxidase; HD: enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase; thiolase: 3-ketoacyl-CoA thiolase; apo C-III: apolipoprotein C-III. Adapted from [23].

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