TY - JOUR
A2 - Ko, Joshua K.
AU - Knoch, Bianca
AU - Barnett, Matthew P. G.
AU - Cooney, Janine
AU - McNabb, Warren C.
AU - Barraclough, Diane
AU - Laing, William
AU - Zhu, Shuotun
AU - Park, Zaneta A.
AU - MacLean, Paul
AU - Knowles, Scott O.
AU - Roy, Nicole C.
PY - 2010
DA - 2010/06/30
TI - Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPAR
SP - 621069
VL - 2010
AB - The interleukin-10 gene-deficient (Il10-/-) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10-/- model. The aims were to (1) characterize colitis onset and progression using a histopathological, transcriptomic, and proteomic approach and (2) investigate links between PPARα and IL10 using gene network analysis. Bacterial inoculation resulted in severe colitis in Il10-/- mice from 10 to 12 weeks of age. Innate and adaptive immune responses showed differences in gene expression relating to colitis severity. Actin cytoskeleton dynamics, innate immunity, and apoptosis-linked gene and protein expression data suggested a delayed remodeling process in 12-week-old Il10-/- mice. Gene expression changes in 12-week-old Il10-/- mice were related to PPARα signaling likely to control colitis, but how PPARα activation might regulate intestinal IL10 production remains to be determined.
SN - 1687-4757
UR - https://doi.org/10.1155/2010/621069
DO - 10.1155/2010/621069
JF - PPAR Research
PB - Hindawi Publishing Corporation
KW -
ER -