Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Table 2

Model parameters from multivariate analysis (PLS) based on liver, IAT and muscle gene expression. R²X: % of variation of X that explained Y; 𝑅²_𝑌cum: % of variation of Y explained by the model; 𝑄²_𝑌cum: % of variation of Y predicted by the model. Cum are for all PLS components.

	PLS component	R^2X(cum)	R^2Y(cum)	Q^2(cum)	P-value
Liver
Oleic 275 gene sequences	1	0.67	0.78	0.76	3.06E-07
Oleic 40-top gene sequences	1	0.94	0.80	0.80	5.00E-08
Trioleate 275 gene sequences	2	0.74	0.86	0.80	3.11E-06
Trioleate 40-top gene sequences	2	0.72	0.89	0.85	2.30E-07
Weight 275 gene sequences	2	0.77	0.96	0.95	4.92E-11
Weight 40-top gene sequences	1	0.75	0.96	0.93	1.80E-14
Liver+IAT+Soleus
Glycemia 846 gene sequences	4	0.71	0.94	0.73	1.00E+00
Glycemia 40-top gene sequences	3	0.86	0.84	0.68	7.00E-03