PPARs in the Renal Regulation of Systemic Blood Pressure

Figure 2

Role of PPAR$\gamma$ in the modulation of the RAAS cascade. Gene expression of RAAS molecules is modulated by PPAR$\gamma$. Although renin production is facilitated by PPAR$\gamma$ activation, the hypertensive effects of RAAS activation are attenuated by PPAR$\gamma$ ligands, since these strongly reduce Ang II levels, ACE and AT-R1 gene expression. Telmisartan also exerts AT-R1 blocking properties. Simultaneously with blockade of AT-R1, the beneficial vasodilator effects of AT-R2 activation become dominant.