Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors

Figure 3

Schematic illustration of the proposed role for PPAR$\gamma$ in the renal collecting duct. PPAR$\gamma$ activation by TZDs or endogenous ligands regulate various epithelial channels/transporters including: (1) epithelial Na⁺ channel (ENaC) either directly or via the Serum- and Glucocorticoid-Regulated Kinase 1 (SGK1); (2) cystic fibrosis transmembrane regulator (CFTR); and (3) AQP water channels. Involvement of PPAR$\gamma$ in the control of ROMK ${\text{K}}^{+}$ and CLC Cl^- channels is still unclear. Furthermore, role of PPAR$\gamma$ in the regulation of paracellular transport, and Na-K-ATPase is also proposed (not shown on this scheme).