Research Article

Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α

Figure 2

Altered expression of proteome maintenance genes by diverse PPC is predominantly PPARα dependent. Wild-type or PPARα-null mice were treated with WY, DEHP, PFOA, or FENO for the indicated times. Hepatic mRNA transcripts were assessed using full-genome Affymetrix arrays. Genes involved in PM including protein chaperones were identified as described in Section 2. (a) Positive control genes. (b) Expression of all PM genes altered by at least one of the treatments. Genes were clustered using one-dimensional hierarchical clustering. All genes are found in Supplemental Material. Red: up-regulation; green: down-regulation; black: no change. The intensity scales indicate fold-change due to chemical exposure relative to controls. Abbreviations: WY: WY-14,643; DEHP: di-(2-ethylhexyl)phthalate; PFOA: perfluorooctanoic acid; FENO: fenofibrate.