Table 3: Average fold change for genes related to lipid metabolism in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

ACAA1acetyl-CoA
acyltransferase 1
1138681.892.921.612.10**1.221.371.53*
ACAA1Bacetyl-CoA
acyltransferase 1B
2356742.382.701.491.40**3.001.091.19*
ACAD10acyl-CoA dehydrogenase,
member 10
719851.512.39−1.181.38**−1.011.051.20*
ACADLacyl-CoA dehydrogenase,
long chain
113633.032.861.401.68**2.501.341.59**
ACADMacyl-CoA dehydrogenase,
C-4 to C-12
113641.701.301.211.31**1.061.111.10
ACADSacyl-CoA dehydrogenase,
C-2 to C-3
668851.031.521.221.31*−1.13−1.12−1.08
ACADSBacyl-CoA dehydrogenase,
short/branched
66885−1.56−1.64−1.04−1.39**−1.261.00−1.23
ACADVLacyl-CoA dehydrogenase,
very long chain
113701.921.801.441.49**1.161.041.12
ACAT1acetyl-CoA
acetyltransferase 1
101446−1.011.101.451.36*−1.55−1.05−1.17
ACAT2acetyl-CoA
acetyltransferase 2
1104602.591.681.141.34*1.261.581.69**
ACOT1acyl-CoA thioesterase 12689719.4873.063.276.82**2.951.532.02
ACOT3acyl-CoA thioesterase 31712812.5532.832.426.41**−1.591.461.86
ACOT2acyl-CoA thioesterase 21712103.8319.291.917.32**1.781.251.52
ACOX1acyl-CoA oxidase 1114305.657.171.231.49**1.511.301.29**
ACSL1acyl-CoA synthetase long-
chain member1
140811.342.361.281.36**1.011.311.30
ACSL3acyl-CoA synthetase long-
chain member3
742052.251.901.281.69**1.111.771.63
ACSL4acyl-CoA synthetase long-
chain member4
507901.952.001.031.42*1.511.341.29
ACSL5acyl-CoA synthetase long-
chain member5
4332563.062.761.241.31**1.381.231.28
ALDH1A1aldehyde dehydrogenase 1,
member A1
116681.561.591.071.12**1.221.161.17
ALDH1A7aldehyde dehydrogenase 1, A7263581.831.861.121.24*1.551.261.35
ALDH3A2aldehyde dehydrogenase 3,
member A2
116713.657.722.103.80**2.301.732.20**
ALDH9A1aldehyde dehydrogenase 9,
member A1
567521.801.911.271.50**1.211.051.11*
CPT1Bcarnitine palmitoyltransferase
1B (muscle)
128962.291.501.232.69**−1.001.131.11
CPT2carnitine palmitoyltransferase II128961.332.541.582.03**1.441.151.34
CYP4A14cytochrome P450, 4, a,
polypeptide 14
1311975.38103.4811.2612.28**12.75−1.092.22
DCIdodecenoyl-CoA
delta isomerase
131772.914.551.902.38**1.991.041.38*
ECH1enoyl CoA hydratase 1,
peroxisomal
517983.275.231.932.49**2.101.161.39
EHHADHenoyl-CoA, hydratase7414727.8922.112.374.34**1.371.321.52*
FABP1fatty acid binding protein 1, liver14080−1.271.021.111.24**1.25−1.09−1.23
HADHATrifunctional protein, alpha unit972122.132.951.371.65**1.011.061.02
HADHBTrifunctional protein, beta unit2310862.333.431.371.60**1.08−1.15−1.28*
HSD17B4hydroxysteroid (17-beta)
dehydrogenase4
154882.032.561.341.45**−1.131.121.20*
SLC27A1solute carrier 27, member 1264579.148.22−1.021.14*−1.571.041.04
SLC27A2solute carrier 27,
member 2
264581.481.801.191.16**1.331.101.05
SLC27A4solute carrier 27,
member 4
265691.871.911.041.31**−1.031.091.07

1From Rosen et al. (2008),
*Significantly different than control (P.03),
**Significantly different than control (P.0025)